A Janus-faced role of the unfolded protein response in antitumor immunity
نویسندگان
چکیده
The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013